The Human Crew first originated in Zil's mind after he and two of his friends jumped into Duck's pool. The surprise and anger of people invading his peaceful spot activated Duck's power, which caused him to sink into the pool's floor, causing a whirlpool that almost killed Zil. This inspired his hatred for mutants.
However, it was only until Hunter killed Harry that his hatred for freaks made Zil turn violent. Many of Zil's friends joined his group to eradicate Perdido Beach of the freaks, including Lance, Lisa, Turk, and Antoine.
At first, all the Human Crew did was break windows and spray graffiti. But, once they found Hunter, they attacked him while he was cooking a deer. Beating him senseless, the Human Crew staged a public hanging, stating if the kids helped hang Hunter they would get deer meat. But, Orc came and saved Hunter and the public hanging turned chaotic. Although, Hunter may not have died, he did suffer a mild brain damage. The Human Crew then retreated.
In Lies, Caine bribes the Human Crew to light Perdido Beach on fire as a distraction so Caine, Diana, Penny, Paint, and Bug can escape to San Francisco de Sales Island unnoticed. They follow through, successfully burning a large portion of Perdido Beach down. Later, when the leader of the Human Crew, Zil, is present at 'Mary's Big Jump', Dekka Talent lifts Zil up using her anti-gravity power and kills him, or to be more precise, he kills him as he tries to shoot Dekka while in midair, and the backfire of the gunshot sends him out of Dekka's range.
By the start of Plague, the only surviving members of Zil's "inner circle" are Lance, Turk, and Lisa. Turk was able to convince the Town Council to let the remaining members if the Human Crew stay in Perdido Beach. However, they were forced to work undesirable jobs such as digging holes for excrement.